a condition of facial difference (craniosynostosis) characterized by a tall head, bulging of the eyes, a receded midface, high arched palate, crowded teeth, broad thumbs and big toes, and usually normal intelligence.
Pfeiffer syndrome is a genetic disorder characterized by the premature fusion of certain bones of the skull (craniosynostosis), which prevents further growth of the skull and affects the shape of the head and face. In addition, the thumbs and big toes are broader and often shorter than normal.