Definitions for "Philadelphia Chromosome"
A reciprocal translocation occurring when the abl gene from chromosome 9 joins with the bcr gene from chromosome 22 to form the hybrid bcr/abl gene. This abnormal gene is almost always found in patients with Chronic Myelogenous Leukemia (CML). It also occurs in adults and children with Acute Lymphocytic Leukemia (ALL). When found in ALL, the patient has a poor prognosis.
Characteristic chromosomal abnormality in which a portion of chromosome 22 is translocated to chromosome 9. The mutation results in a fused BCR-ABL gene, which encodes the Bcr-Abl tyrosine kinase believed to be responsible for causing chronic myelogenous leukemia. The Philadelphia chromosome is found in virtually all cases of chronic myelogenous leukemia and some cases of acute lymphoblastic leukemia.
An abnormal chromosome that is formed when part of chromosome 9 attaches to chromosome 22 (translocation). This abnormality is found in nearly all cases of chronic myeloid leukemia. Also called as Ph1.