A syndrome where cancer treatment causes massive cancer cell death that results in the build up of uric acid crystals and other chemicals in the blood stream (such as sodium and potassium).
release into the blood large amounts of intracellular protein, nucleic acids and other breakdown products resulting from rapid lysis of tumors causing renal toxicity and serum electrolyte imbalances.
Arises from the death of certain large tumors and may arise shortly after chemotherapy is started. It is characterized by symptoms of kidney failure owing to excessive amounts of calcium, phosphate, and potassium being released by dying tumors. See "Metabolic Imbalances" in Chapter 9, Side Effects of Treatment.
A side effect of chemotherapy that results from the rapid breakdown of leukemia cells. When leukemia cells are destroyed, they release breakdown products and minerals into the bloodstream, which may affect the kidneys, heart, and nervous system. This condition can be prevented by giving extra fluids and certain drugs, such as sodium bicarbonate, and allopurinol, which help the body dispose of these substances. Tumor lysis syndrome is more common with acute leukemia than with chronic leukemias.
A complication that can occur after having chemotherapy treatment.
In medicine (oncology and hematology), tumor lysis syndrome (TLS) is a term given to a group of metabolic complications that occur after treatment of neoplasms, usually lymphomas and leukemias. These disorders include hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia, and acute renal failure.
