A category of myeloma characterized by comparatively low amounts of myeloma- associated protein levels and bone marrow plasma cells as well as an absence of certain myeloma-related symptoms (i.e., anemia, renal failure, hypercalcemia, and lytic lesions).
Precancerous and asymptomatic condition noted by the presence of M protein in the serum or urine. MGUS may progress to myeloma.
A condition in which M-proteins, a sign of multiple myeloma, are found in the blood, and in which there are no other signs or symptoms of cancer. Patients with this condition may develop multiple myeloma, other plasma cell neoplasms or lymphoma.
MGUS. A benign condition in which there is a high level of a protein called M protein in the blood. Patients with MGUS are at an increased risk of developing cancer.
Monoclonal gammopathy of undetermined significance (MGUS, unknown or uncertain may be substituted for undetermined) is a condition in which a low or non-quantifiable level of a monoclonal paraprotein is detected in the blood by means of protein electrophoresis. In addition, some patients develop a polyneuropathy (damage to peripheral nerves) or other problems related to the secreted antibody. MGUS is distinct from multiple myeloma, as described below.