A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).
The oldest (first century AD) and among the most popular drugs for treatment of Gout. Colchicine is a potent poison in larger doses, similar in effect to Arsenic. Even in medicinal doses it can cause nausea. While Colchicine works efficiently to end gout flares, it often will increase pain somewhat in the early stages of an attack before showing a benefit. A newer treatment combines a sub-clinical dose of Colchicine with the drug Probenecid to prevent increased early-stage discomfort.
an alkaloid that inhibits the formation of the spindle and delays the division of centromeres; used to produce polyploid varieties of horticulturally important species; also used to stop mitosis at metaphase for preparation of karyotypes
A substance found in a plant that is used in clinical medicine for the treatment of gouty arthritis and in the laboratory to arrest cells during cell division (by disrupting the spindle) so their chromosomes can be visualized. The name colchicine is from the Greek kolchikon meaning autumn crocus or meadow saffron, the plant from which colchicine was originally isolated.
A compound that blocks the assembly of microtubules-protein fibers necessary for cell division and some kinds of cell movements, including neutrophil migration. Side effects may include diarrhea, abdominal bloating, and gas.
Colchicine is a highly poisonous alkaloid, originally extracted from plants of the genus Colchicum (Autumn crocus, also known as the "Meadow saffron"). Originally used to treat rheumatic complaints and especially gout, it was also prescribed for its cathartic and emetic effects. Its present medicinal use is mainly in the treatment of gout; as well, it is being investigated for its potential use as an anti-cancer drug.