Enzyme involved in prostaglandin synthesis; there are at least two isoforms: COX-1 and COX-2.
An enzyme, also known as COX, that makes prostaglandins from a molecule called arachidonic acid; the molecular target of nonsteroidal anti-inflammatory drugs.
An enzyme involved in thromboxane and prostaglandin synthesis. Inhibition of COX is responsible for the anti-inflammatory action of non-steroidal anti-inflammatory drugs (NSAID), such as ibuprofen and aspirin.
enzyme that oxidizes arachidonic acid to prostaglandin; COX-1 is a form of cyclooxygenase involved in regular body systems such as kidney function and stomach protection; COX-2 is triggered by inflammatory mechanisms.
(COX) Definition: Cycloogygenase (COX) exists in two forms, COX-1 and COX-2. COX-1 is found in most cells (including platelets) as a constitutive enzyme, whereas COX-2 is induced in inflammatory cells by various stimuli. Cycloogynase possesses an endoperoxide synthase and a peroxidase activity which leads to the conversion of arachidonic acid via prostaglandin G2 (PGG2) into prostaglandin H2 (PGH2). PGH2 can than be further converted into different bioactive prostanoids including thromboxane A2, prostaglandin E and prostacyclin.
either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
The enzyme required for the conversion of fatty acids, such as arachidonic acid, to eicosanoids. Many anti-inflammatory drugs, such as aspirin, act by inactivating this enzyme. Omega-3 fatty acids react with cyclooxygenase enzyme to produce less harmful eicosanoids.
Enzyme complex present in most tissues that produces various prostaglandins and thromboxanes from arachidonic acid.
enzyme involved in one of the pathways of arachidonic acid metabolism; leads to the formation of proinflammatory mediators
Abbreviated cox. See: Cox-1; Cox-2.
an enzyme involved in oxygen metabolism. Cyclooxygenase is part of the pathway that mediates bodily response to infection and injury (e.g., inflammation and pain) via substances such as histamine and prostaglandins.
Refers to a particular enzyme involved in the formation of prostaglandins in the body. These may be important in the natural physiology in a particular organ or cell, or may be involved in the formation of prostaglandins that induces inflammation in a joint, in which case it may be detrimental.
An enzyme that plays a pivotal role in the synthesis of prostaglandins.
Cyclooxygenase (COX) is an enzyme that is responsible for formation of important biological mediators called prostanoids (including prostaglandins, prostacyclin and thromboxane). Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain; this is the method of action of well-known drugs such as aspirin and ibuprofen.