Definitions for "Nucleoside Analog"
Related Terms:
Nucleoside analogue, Nucleoside reverse transcriptase inhibitor, Nrti, Non-nucleoside reverse transcriptase inhibitor, Reverse transcriptase inhibitor, Non-nucleoside reverse transcriptase inhibitors, Nnrti, Protease inhibitor, Protease inhibitors, Delavirdine, D4t, Ddc, Saquinavir, Haart, Nevirapine, Stavudine, Lamivudine, Antiretroviral, Didanosine, Highly active antiretroviral therapy, Crixivan, Reverse transcriptase, Thymidine kinase, Zidovudine, Indinavir, Integrase, Abacavir, Nef, Rt-pcr, Env , Retrovirus, Ddi, Reverse transcription, Ritonavir, Amprenavir, Retroviruses, Gp160, Endogenous retrovirus, Combivir, Azt, Long terminal repeat, Nelfinavir, Retrotransposon, Complementary dna, Topoisomerase, Helicase, Gag , Polymerase, Antisense
also known as NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR, NRTI): a compound (e.g., AZT, d4T, 3TC) that mimics one of the building blocks of DNA. These compounds suppress retroviral replication by interfering with the reverse transcriptase enzyme.
An HIV drug, acting to replace natural nucleosides and block the completion of the viral DNA chain during infection of a new cell by HIV.
(See Purine analog).
A type of synthetic antiviral drug, such as AZT, ddI, ddC, d4T, or 3TC, whose makeup constitutes a defective version of a natural nucleoside. Nucleoside analogs may take the place of the natural nucleosides, blocking the completion of a viral DNA chain during infection of a new cell by HIV. The HIV enzyme reverse transcriptase is more likely to incorporate the nucleoside analogs into the DNA it is constructing than is the DNA polymerase normally used for DNA creation in cell nuclei. See Nucleic Acid.
an artificial copy of a nucleoside. When incorporated into the DNA or RNA of a virus during viral replication, the nucleoside analog acts to prevent production of new virus. Nucleoside analogs may take the place of natural nucleosides, blocking the completion of a viral DNA chain during infection of a new cell by HIV. The HIV enzyme reverse transcriptase is more likely to incorporate the nucleoside analogs into the DNA it is constructing than is the DNA polymerase normally used for DNA creation in cell nuclei.
A general type of antiretroviral drug (i.e., AZT, ddI, ddC, 3TC, and d4T) which resemble some of the building blocks needed to make RNA and DNA. They work by interfering with the reverse transcriptase enzyme and, thus, interrupting HIV's replication process.
a compound (e.g., AZT, ddI, ddC, d4T, 3TC) that mimics one of the building blocks of DNA and RNA. These compounds suppress retroviral replication by interfering with the reverse transcriptase enzyme. The defective synthetic nucleosides cause premature termination of the viral DNA chain. Nucleoside analogs are prodrugs that are converted into active agents by phosphorylation.
a type of ANTIVIRAL drug, such as AZT (ZIDOVUDINE), ddI (DIDANOSINE), ddC (DIDEOXYCYTIDINE) or d4T (STAVUDINE), whose structure constitutes a defective version of a natural NUCLEOSIDE. Nucleoside analogs may take the place of the natural nucleosides, blocking the completion of a viral DNA chain during infection of a new cell by HIV. The HIV enzyme REVERSE TRANSCRIPTASE is more likely to incorporate nucleoside analogs into the DNA it is constructing than is the DNA POLYMERASE that cells normally use for DNA construction.
a compound (e.g., AZT, ddI, ddC, d4T, 3TC, abacavir) that mimics one of the building blocks of DNA. These compounds suppress retroviral replication by interfering with the reverse transcriptase enzyme; the synthetic nucleosides cause premature termination when they are inserted into the viral DNA chain being built.
A type of antiviral drug, such as AZT, ddI, ddC, d4T, 3tc, or abacavir whose structure constitutes a defective version of a natural nucleoside. Like NNRTIs, these drugs block the viral enzyme responsible for converting HIV RNA into DNA, ultimately preventing the cell from becoming infected.
Artificial copy of a nucleoside that will prevent production of new virus by inserting itself into a virus DNA or RNA during viral replication. Nucleoside analogs may take the place of natural nucleosides, blocking the completion of a viral DNA chain during infection of a new cell by HIV.