Anemia from an underlying autoimmune digestive disorder.
A condition caused by insufficient absorption of vitamin B12 from the intestine, regardless of food intake, due to a lack of vitamin B12 binding protein in the gut. It is characterized by anemia, degeneration of the spinal cord, and, if untreated, sore tongue, weakness, weight loss, back pain, tingling of extremities, apathy, and mental and nervous abnormalities. A daily intramuscular injection of B12 will restore normal blood count and cause symptoms to disappear.
A form of anemia, which means less than the normal level of circulating red blood cells. This condition is caused by an inappropriate autoimmune process in which the immune system attacks and damages certain cells lining the stomach. As a result, vitamin B12 is not absorbed properly from food that is consumed. Vitamin B12 is necessary for proper red blood cell production.
A form of anemia (low red blood cell count) that results when the bone marrow fails to produce adequate numbers of red blood cells due to a deficiency in vitamin B12.
A chronic, macrocytic anemia caused by a defect in production of “intrinsic factor” by the stomach. There is accompanying megaloblastic erythropoiesis, poikilocytosis, granulocytic hypersegmentation, achlorhydia, and neurological disturbances.
also known as addisonian anemia; a severe hyperchromic anemia marked by a progressive decrease in number and increase in size and hemoglobin content of the red blood cells and by pallor, weakness, and gastrointestinal and nervous disturbances and associated with reduced ability to absorb vitamin B 12 due to the absence of intrinsic factor
One form of anemia associated with a lack of vitamin B12 and other factors. Usually responds to B12 and iron diet.
a chronic progressive anemia of older adults; thought to result from a lack of intrinsic factor (a substance secreted by the stomach that is responsible for the absorption of vitamin B12)
Classically, PA is only used to describe an autoimmune disease in which the part of the stomach where intrinsic factor is secreted has been attacked by the body's immune system, rendering Vitamin B12 unabsorbable in the terminal ileum and thus causing anemia. However, some physicians also use PA to describe general Vitamin B12 deficiency regardless of the cause.
A chronic, progressive condition of older adults characterized by numbness and tingling, weakness, a sore smooth tongue, shortness of breath, faintness, loss of appetite, diarrhea, weight loss, and fever. Caused by the lack of intrinsic factor which is needed to absorb vitamin B12.
A macrocytic megaloblastic anemia caused by a deficiency of vitamin B12.
A megablastic anemia usually occurring in later adult life characterized by the reduced ability to absorb B-12 from the gastrointestinal tract due to a failure of gastric mucosal secretion of intrinsic factor.
A rare but dangerous deficiency of vitamin B12 that can lead to low red blood cell counts and nervous system impairment.
serious form of anemia (decreased number of circulating red blood cells) caused by a deficiency of vitamin B12, often as a result of lack of secretion of intrinsic factor by the stomach
Autoimmune disease in which antibodies are directed towards the parietal cells of stomach. Parietal cells secrete acid and intrinsic factor (necessary for absorption of vitamin B12). B12 deficiency causes dysmaturation of red blood cells which become enlarged (megaloblastic).
An anemia (low blood counts) caused by lack of vitamin B12.
decreased number of circulating red blood cells due to lack of folic acid or vitamin B12.
A blood disorder caused by inadequate vitamin B12 in the blood. Patients who have this disorder do not produce the substance in the stomach that allows the body to absorb vitamin B12. This substance is called intrinsic factor (IF). See the entire definition of Pernicious anemia
A form of anemia or a less than normal level of circulating red blood cells. This condition is caused by an inappropriate autoimmune process that misdirects an immune response against the lining of the stomach. As a result, the stomach lining is damaged and vitamin B12 is not absorbed properly from food that is consumed. Vitamin B12 is necessary for proper red blood cell production.
A severe blood disease where there is a decrease in number and increase in size of red blood cells. The illness is characterized by pallor, weakness and the inability to absorb vitamin B12.
A type of anemia (low red blood cell count) caused by the body's inability to absorb vitamin B12.
(per-NISH-us a-NEE- mee-a): A type of anemia (low red blood cell count) caused by a lack of vitamin B12.
Anemia caused when your stomach stops making intrinsic factor and you stop being able to absorb cobalamin from your food.
(per-NISH-us a-NEE-mee-a): A blood disorder caused by a lack of vitamin B12. Patients who have this disorder do not produce the substance in the stomach that allows the body to absorb vitamin B12.
a type of megaloblastic anemia in which the body does not absorb enough Vitamin B-12 from the digestive tract.
A deficiency of the oxygen-carrying red blood cells that often occurs in people with autoimmune diseases of the thyroid gland.
reduction in red blood cells generally occurring in later adult life due to the inability to absorb B12 from the gastrointestinal tract
a potentially dangerous form of anemia, usually caused by an autoimmune process, which results in a deficiency of vitamin B-12.
Anemia caused by a lack of vitamin B12. The body needs B12 to make red blood cells.
A form of anemia ( the decreased ability of red blood cells to provide adequate oxygen to body tissues) caused by the lack of a protein called intrinsic factor which is necessary for the absoption of vitamin B12 from the gastrointestinal track. More information.
he end stage of an autoimmune inflammation of the stomach, resulting in destruction of stomach cells by one's own antibodies. Progressive destruction of the cells that line the stomach cause decreased secretion of acid and enzymes required to release food bound vitamin B-12. Antibodies to intrinsic factor (IF) bind to IF preventing formation of the IF-B-12 complex, further inhibiting vitamin B-12 absorption.
an anemia due to the lack of intrinsic factor (a substance secreted by the stomach.) Lack of intrinsic factor results in reduced absorption of B12.
Anemia caused by a vitamin B12 deficiency.
Anemia due to the production of an autoantibody against the parietal cells and a blocking antibody that blocks the binding of vitamin B12 to the intrinsic factor. A third autoantibody blocks the absorption of the B12-intrinsic factor complex . Megaloblastic anemia (anemia characterized by many large immature and dysfunctional red blood cells - megaloblasts - in the bone marrow) results from the lack of B12. find all NHC pages containing: pernicious anemia
Pernicious anemia refers to a type of autoimmune anemia. Antibodies are directed against intrinsic factor or parietal cells which produce intrinsic factor. Intrinsic factor is required for vitamin B absorption, so impaired absorption of 12}} can result.