A group of diseases characterized by the production of Hb S resulting from the inheritance of two betas globin genes (Hb SS), a beta S and a beta C gene (Hb SC), a beta S and a beta-thalassemia gene (Hb S beta-thalassemia), or a beta S gene and a gene for other abnormal hemoglobin which polymerizes with Hb S.
an inherited abnormality of the haemoglobin which causes distortion of the red blood cells (sickling) under low oxygenation conditions. It mostly affects people of African, African/Asian Caribbean, Eastern Mediterranean, Asian and Middle Eastern origin. Individuals who inherit the gene from each parent have sickle cell disease associated with anaemia and sickle cell crises.
a genetic disease that causes red blood cells to be sickle-shaped rather than round. In order to have sickle cell disease, a baby must inherit the gene from both the mother and the father. When a baby inherits only one gene this is called sickle cell trait. These babies have few health problems. Many states test infants for this disease. If sickle cell disease is detected, early treatment is advised.
a hereditary disorder in which red blood cells are sickle-shaped, causing impaired circulation
A recessive, inherited genetic disorder common to people of African descent causing abnormal oxygen-carrying capacity in red blood cells, resulting in anemia, fatigue and delayed growth and development
A group of inherited disorders in which anemia is present and sickle hemoglobin is produced.
An inherited disorder of the red blood cells in which one gene is for sickle hemoglobin (S), and the other gene is for another unusual hemoglobin such as S, C, Thal. etc. The following are examples of sickle cell disease: SS, SC, SD, SßThal, etc.
A blood condition seen most commonly in people of African ancestry. The disorder is caused by a single base pair change in one of the genes that codes for hemoglobin, the blood protein that carries oxygen. This mutation causes the red blood cells to take on a sickle shape, rather than their characteristic donut shape. Individuals who suffer from sickle cell disease are chronically anemic and experience significant damage to their heart, lungs, and kidneys.
A chronic, usually fatal anemia marked by sickle-shaped red blood cells, occurring almost exclusively in Black people of Africa or of African descent, and characterized by episodic pain in the joints, fever, leg ulcers, and jaundice. The disease occurs in individuals who are homozygous for a mutant hemoglobin gene.
a inherited disease that causes an abnormality in the red blood cells in which the red blood cells become sickle shape.
A genetic blood disease due to the presence of an abnormal form of hemoglobin, namely hemoglobin S . Hemoglobin is the molecule in red blood cells that transports oxygen from the lungs to the farthest reaches of the body. See the entire definition of Sickle cell disease
an inherited disorder that occurs primarily in African-Americans and causes a severe form of anemia.
Sickle cell anemia is an inherited blood disease that affects red blood cells. Normal red blood cells are smooth and round. In sickle cell anemia, the red blood cells become hard, sticky, and shaped like sickles or crescents. Their shape causes them to block the flow of blood in blood vessels. Resulting symptoms can include joint pain, headaches and anemia. Persons with sickle cell disease can require frequent transfusions. For more information on sickle cell disease from the National Heart, Lung, and Blood Institute, click here.
A disease in which the affected person makes an abnormal hemoglobin. Sickle cell disease is inherited.
Genetic blood disorder common in regions of Africa and other areas where malaria is found and among descendants of these regions. Abnormal blood cells carry insufficient oxygen.
A genetic disorder producing crescent shaped red blood cells that result in anemia and blood cell clumping.
an inherited autosomal recessive condition that causes abnormal hemoglobin in blood cells, leading to infections, pain, and organ damage. Occurs primarily in persons of African-American descent.