The CLEO collaboration is a team of over 150 high energy physicists from 25 universities studying the production and decay of beauty and charm quarks and tau leptons produced in the Cornell Electron Storage Ring (CESR). Armed with the versatile and powerful CLEO III detector, and a large sample of B mesons accumulated with the CLEO II detector, the collaboration makes some of the most sensitive tests of the Standard Model of elementary particles, key to understanding the forces of nature and the fundamental structure of matter.