The altering of genes in order to affect their function.
Experimental, futuristic technology for introducing the normal version of a gene into a person who is ill due to the absence of the normal form of a gene. In theory, gene therapy could be used some day to make the skin surface of XP patients resistant to sunlight, although this is unlikely to be possible for several years. Potential problems include difficulty of treating most types of cells in the body (e.g., eye and brain cells), possibility of the treatment not working indefinitely, and possible side effects such as allergic reactions or cancers.
an experimental procedure in which disease-causing genes are replaced by normal, healthy genes
An experimental procedure to treat genetic disorders by inserting healthy genes into the body to replace damaged ones.
Medical treatment by changing of DNA.
the treatment of medical disorders by introducing specific engineered genes into a patient’s cells
The process by which a person's genomic information is analysed and a copy of the useful genes are inserted into a subject cell. Using this process, advantages genes were inserted into soldiers to create Genome Soldiers with strong battle skills. These become the Next Generation Special Forces.
A set of techniques used to treat inherited diseases. A healthy gene is inserted into the cells of a patient's body to counteract or overcome the effects of the defective gene.
An experimental medical technique that relies on the insertion of genes into an individual's cells and tissues to treat a disease. Typically, a defective gene is replaced by a normally functioning one. The normal gene is delivered to target tissues in most cases by an adenovirus that has been genetically altered to render it harmless.
use of genes to treat disease
The insertion of normal DNA directly into cells to correct a generic defect.
Replacement or augmentation of a dysfunctional gene for medical purposes.
Treatment that alters genes (the basic units of heredity found in all cells in the body). This treatment may involve the addition of a functional gene or group of genes to a cell by gene insertion to correct a hereditary disease.
Transfer of selected genes into a host with the hope of ameliorating or curing a disease state.
The delivery of exogenous DNA to mammalian cells to cause the expression of this material thereby altering the cells phenotypically.
A novel approach to treat, cure, or ultimately prevent disease by changing or repairing defective genes.
The use of genetic material for therapeutic purposes. The therapeutic gene is typically delivered using recombinant virus or liposome based delivery systems.
The introduction of new genetic material to damaged genes or cancer cells. The goal of gene therapy is to replace damaged cells with healthy ones, or to make cancer cells more sensitive to the effects of the immune system, immunotherapy, and chemotherapy.
The treatment of genetic disease accomplished by altering the genetic structure of either somatic (nonreproductive) or germline (reproductive) cells.
adding healthy genes to a person with disease affected genes .(Church et al., 2002)
An experimental approach involving the intentional alteration of genetic makeup to affect a phenotypic change. For example, when a 'normal' gene is inserted into cells to replace a 'malfunctioning' gene that is causing some disease or condition.
A method that attempts to cure an inherited disease by providing the patient with a functioning copy of the defective gene.
A form of treatment that attempts to alter genes to improve the body's natural ability to fight disease or to make tumors more sensitive to other kinds of therapy.
Treatment of a genetic disease by providing patients with cells containing wild type alleles for the genes that are nonfunctional in their bodies.
the delivery of a gene or genetic information into cells for the purpose of achieving a therapeutic effect, that is, a treatment or a cure.
Treatment that alters genes. Using genes to stimulate the immune system. In studies of gene therapy for cancer, researchers are trying to improve the bodyâ€(tm)s natural ability to fight the disease and to make the tumor more sensitive to other kinds of therapy. Treatment focuses on replacing damaged or missing genes with healthy copies.
Treatment of a hereditary disease by inserting a functional gene into the appropriate cells of the body.
The use of DNA introduced into a cell or animal to cause the expression of a particular protein, often one that can replace a missing or defective protein that may be responsible for a disease.
A treatment that changes the structure of the genes. It may be used to help the body fight cancer, or to alter cancer cells to make them more susceptible to treatment.
Treating genetic disorders by inserting a correct copy of the gene in question, into the cells of individuals who have a disorder due to a mutated gene. (See Genetics Fact Sheet No 25: Gene Therapy).
an approach to treat, cure, or ultimately prevent disease by changing the makeup of a person's DNA.
Any of number of experimental treatments in which genes are altered.
the genetic modification of body cells of an individual patient, directed to alleviating disease in that patient.
Gene therapy is the process of introducing genetic material (DNA or RNA) into a person's cells to fight disease. Gene therapy is being studied in clinical trials (research studies with humans) for many different types of cancer and for other diseases. Researchers are studying several ways to treat cancer using gene therapy. Some approaches target healthy cells to enhance their ability to fight cancer. Other approaches target cancer cells, to destroy them or prevent their growth. Gene therapy is the treatment of disease by either replacing damaged or abnormal genes with normal ones, or by providing new genes to fight diseases such as cancer.
Treatment of hereditary disease via the replacement of the defective gene with a healthy one.
substitution of a defective gene in patients with a functional one.
a newly evolving technique used to treat inherited genetic diseases. The medical procedure involves substituting the defective gene in the cells of a patient's body with a healthy gene.
A means of treating or correcting genetic disorders by introducing the normal or functioning gene into the cells of individuals who lack the normal gene.
A treatment method that involves the manipulation of an individual's genetic makeup. Gene therapy makes changes to an individuals DNA to correct a genetic condition.
The introduction of healthy genetic material to replace, augment or influence genes that do not function properly. In some cases the material can be injected with what is known as a genetic vaccination. In other cases the material is introduced through bioengineered viruses that carry the therapeutic gene to the cell. Globules known as liposomes can also be used to carry therapeutic genes to specific cells.
the administration of genetic material into cells of a patient to correct or replace a specific gene that is not working properly
an experimental treatment that involves introducing genetic material (DNA or RNA) into a persons cells to fight disease
an important method to treat many diseases
An experimental medical technique that aims to treat an illness by replacing a faulty or missing gene with a working copy, or by switching off a harmful gene.
the use of genes to treat cancer and other diseases.
the deliberate introduction of nucleic acids into human somatic cells for therapeutic, prophylactic or diagnostic purposes
the treatment of disease by replacing or changing non — functioning genes.
The medical technique which involves replacing nonfunctional genes with healthy genes.
A method of treating diseases that involves inserting new genetic material into a patient's cells.
(jeen THER-ah-pee) Insertion of normal or genetically altered genes into cells to replace defective genes, especially in the treatment of genetic disorders
The introduction of new genes into individuals to cure diseases or genetic abnormalities.
Experimental treatment of a genetic disorder by replacing, supplementing, or manipulating the expression of abnormal genes with normally functioning genes
The use of genetic intervention to treat disease. Techniques (still mostly experimental) include treatment of a genetic defect by insertion of a normal gene (e.g. cystic fibrosis), blockade of expression of an abnormal gene (e.g. the BCL2 leukaemia gene) with antisense technology and the introduction of a gene for an enzyme that converts a pro-drug into a cytotoxic metabolite (e.g. thymidine kinase to convert 5-fluorocytosine to 5-fluorouracil). See also Retrovirus, Transduction.
The addition of a functional gene or groups of genes to a cell using recombinant DNA techniques (see gene splicing) to correct a hereditary disease.
healing of diseases by introducing intact genes into "sick" somatic (body) cells. The information changed in the somatic cells is not passed on to its descendants
possible future treatment for genetic disorders by replacing a faulty or missing gene with a fully functioning gene.
a therapy to replace defective genes responsible for retinal degenerations, such as macular degeneration. This therapy currently is under investigation in the laboratories at the Emory Eye Center.
Treatment of inherited disease by addition, insertion or replacement of a normal gene or genes.
The treatment of genetic disease by either repairing the defective gene or replacing it with a functioning gene.
a scientific method to replace disease-causing genes with normal ones.
An evolving technique used to treat genetic diseases. The medical procedure involves replacing, manipulating or supplementing non-functional genes with healthy genes so that they can function normally.
An experimental technique that, in hemophilia, involves taking normal genes (the ones that tell the body to make clotting factor) and placing them into the body of a person with hemophilia, in hopes that his body will begin to make clotting factor on its own.
A method of replacing, manipulating or supplementing a dysfunctional gene with a functioning one. This evolving technique is currently being researched in several inherited diseases, including hemophilia. There is hope that gene therapy will lead to better treatments, and eventually cures.
Treating diseases by replacing the defective gene, either by incorporating a normal copy of the gene in the germ-cells (egg or sperm) or in the embryo (germline gene replacement therapy), or by supplying copies of the normal gene to be taken up and incorporated into cells of the adult (somatic cell gene replacement therapy).
The treatment of disease by replacing, manipulating, or supplementing nonfunctional genes.
A newly evolving technique used to treat inherited genetic diseases. The medical procedure involves adding a healty gene into the cells of a patient's body, overcoming the effects of the defective gene.
Introduction of a fully functional and expressible gene into a target cell, aimed at correcting a specific disease permanently.
A new approach to treating medical conditions, which can be described as the use of genes as drugs. It works by introducing normal genes into people with certain disorders to overcome the effects of defective genes that may cause or have a part to play in the development of the condition. Gene therapy can also be used to treat disorders where the genetic cause is not known, or may not be caused exclusively by genetic defects, such as Parkinson's. See PDS information sheet Gene Therapy (FS49) - 575kb pdf format.
An experimental process whereby the proteins which come from missing or deficient genes could be produced within the body following administration of genes into the body's muscle or liver. It's believed that if the missing or deficient genes can be replaced and caused to function normally, then the missing protein could be produced in a more natural way, possibly leading to the need for fewer intravenous administrations of augmentation therapy.
The treatment of disease by replacing or manipulating damaged or abnormal genes with normal ones.
A technique involving the use of foreign genetic material to correct a genetic defect or to modify the phenotype of an affected individual, by targeting the somatic cells.
The delivery of a gene or genetic information into cells for the purpose of achieving a therapeutic effect. Two forms of gene therapy-gene replacement therapy and ribozyme therapy-have shown promise in the treatment of retinal degenerative diseases.
A method using genes (sequences of DNA) to treat disease.
Treatment of genetic diseases by providing the correct or normal form of the abnormal gene causing a disease.
involves the insertion of a functional gene or another molecule that contains and information sequence into a cell to achieve a therapeutic effect
Treating cancer by repairing gene damage, or blocking the proteins that damaged genes make.
Replacement of a defective gene with a normal copy in order to cure a genetic disorder.
inserting the normal gene into a person, to replace a non-working or missing gene.
A method of treating genetic conditions by inserting a correct copy of the gene in question into the cells of individuals who have a mutated gene.
An experimental procedure aimed at replacing, manipulating, or supplementing nonfunctional or misfunctioning genes with healthy genes. Source : Human Genome Project Information
A therapeutic strategy aimed at introducing genes into an organism for the purpose of correcting genetic defects.
The replacement of a defective gene in an organism suffering from a genetic disease. Recombinant DNA techniques are used to isolate the functioning gene and insert it into cells. Over three hundred single gene disorders have been identified in humans. A significant percentage of these may be amenable to gene therapy.
an approach to preventing and/or treating disease by replacing, removing or introducing genes or otherwise manipulating genetic material. Examples include adding a gene to a cell to produce a specific missing protein, using antisense molecules to prevent viral replication, and altering CD4 cells to make them resistant to HIV infection. Genes may be introduced by direct injection or using a harmless viral vector to deliver genes into cells.
Therapeutic approach that delivers a gene for a product (protein) rather than the product itself.
a method of treating a disease by exchanging the defective gene causing the disease with a healthy one in a cell.
techniques that introduce new genetic material into a patient, correcting genetic defects that are causing disease.
The introduction of normal genes into cells in place of missing or defective ones in order to correct genetic disorders. The technique is still experimental.
Correction of a genetic defect by gene manipulation or by inserting a functioning gene into the cells of an individual.
An experimental approach in which a baulky gene is replaced with a correct one, delivered into cells by a disabled virus. The treatment is mired in controversy after the death of a young US volunteer with a liver disorder and after two French babies, treated for a severe disorder of the immune system, fell sick with leukaemia. This has shown how much has still to be learnt about how genes interact and the importance of slotting the replacement gene at the right spot in the chromosome.
an innovative treatment that affects the way the body recognizes cancerous cells.
An evolving technique involving replacement, manipulation, or supplementation of nonfunctional genes with healthy genes.
The technology that uses genetic material for therapeutic purposes. This genetic material can be in the form of a gene, representative of a gene or cDNA, RNA, or even a small fragment of a gene. The introduced genetic material can be therapeutic in several ways: It can make a protein that is defective or missing in the patient's cells (as would be the case in a genetic disorder), or that will correct or modify a particular cellular function, or that elicits an immune response.
Therapy of a genetic disease caused by DNA modifications by inserting the correct DNA into the affected cells and insertion of the DNA into the genome.
Gene therapy is an experimental form of treatment that involves substituting normal genes for abnormal or missing genes. The genetic insertion can be performed either inside the living body or in extracted cells that are then returned to the body.
a new type of treatment that is used to correct a genetic defect.
treating disease by replacing, manipulating, or supplementing nonfunctional genes.
An evolving technique used to treat inheritied diseases. The medical procedure involves either replacing, manipulating, or supplementing nonfunctional genes with healthy genes.
The insertion of genes into selected cells in the body for medical reasons; addition of a functional gene or group of genes to a cell to correct an hereditary disease
a new type of treatment in which defective genes are replaced with normal ones. The new genes are delivered into the cells by viruses or proteins.
A way of treating disease, whereby damaged or abnormal genes are replaced with normal ones, or new genetic instructions are provided to help fight disease.
the replacement of a defective gene in a person or organism suffering from a genetic disease.
The insertion of normal or genetically altered genes into cells, usually to replace defective cells.
Treating a disease by putting good copies of a gene into cells. For cancer, this might include putting genes into the cancer cells that will make them stop growing out of control, or it might mean putting genes into the cancer cells that will make them self-destruct.
Treating disease by replacing, altering, or supplementing genes that are defective, missing, or not functioning.
insertion of genes into an individual's cells and tissues to treat a disease by getting them to make missing factors.
Gene therapy of either kind should be clearly distinguished from the use of genomics to discover new targets for drug discovery and new diagnostic tools. See germ line gene therapy and somatic cell gene therapy.
treatment that alters a gene. In studies of gene therapy for cancer, researchers are trying to improve the body's natural ability to fight the disease or to make the cancer cells more sensitive to other kinds of therapy.
Gene therapy consists of inserting a DNA fragment into a group of cells in which it is absent. (IOescholarlib) Terapia gênica... introduzindo no organismo o gene correto ou substituindo aquele defeituoso", uma antecipação da terapia gênica. (POUniverRS)
Using or altering genes to help cure diseases.
Is a treatment method that involves the manipulation of an individual's genetic makeup. A form of therapy that attempts to fix the defective gene which is causing the disease.
(human): Insertion of normal DNA directly into cells to correct a genetic defect.
treatment of a disease by introducing a new gene into a cell. The new gene may be used to replace a function that is missing because of a defective gene, to help protect normal cells from the effects of drugs (such as those used to treat cancer), or to protect cells from viruses, such as the AIDS virus.
A potential method of treatment for genetic disorders which involves making correct copies of the gene in question and then transporting them into the cells of the body.
A technique for the treatment of genetic disease in which a gene that is absent or defective is replaced by a healthy gene.
an approach to preventing and/or treating disease by replacing, removing or introducing genes or otherwise manipulating genetic material. In some cases, the material can be injected with a genetic vaccination. In other cases the material is introduced through harmless bioengineered viruses that carry the therapeutic gene to the cell. Globules known as liposomes can also be used to carry therapeutic genes to specific cells
The injection of healthy genes into the bloodstream for the purpose of curing a hereditary disease.
Gene therapy is the transfer of normal or redesigned genes into a patient to reduce or cure a disease state. Certain potentially cancerous genes are dormant in all of us and are sometimes triggered into activity. Other genes, tumor-suppressor genes, act naturally to stop unregulated growth of cancer cells. Since the early 1990s, scientists have conducted clinical trials to stop or reverse the activation of cancerous genes or to increase the number and effectiveness of tumor-suppressor genes.
A technique for correcting defective genes responsible for disease development. There are numerous approaches for correcting faulty genes and their application to glaucoma is currently being studied.
The transfer of DNA or RNA into human cells to treat disease using various delivery methods, including improving membrane permeability to DNA, microinjection and the use of viral vectors.
The treatment of disease by replacing, altering, or supplementing a gene that is absent or abnormal and whose absence or abnormality is responsible for a disease
The medical replacement or repair of defective genes in living cells.
Therapies that alter the genetic structure of tumor cells, making them more susceptible to either the immune system or chemotherapy drugs.
set of therapeutic approaches involving the transfer of genetic information to cells, tissues or organs of a patient, in order to overcome a genetic default or to provide a protective or corrective function.
The treatment of disease by either replacing damaged or abnormal genes with normal ones, or by providing new genetic instructions to help fight disease, e.g., cancer. Therapeutic genes are transferred into the patient either through a weakened virus, a non-viral vector, or through direct delivery of so-called "naked" DNA.
Gene therapy is a treatment method which involves the manipulation of and individuals genetic makeup. Keratin Keratin is a kind protein that is present in hair and nail.
A sophisticated medical procedure that treats a disease by altering the genetic structiure of diseased cells.
An approach to preventing and/or treating diseases by replacing, removing, or altering key genes, or otherwise manipulating genetic material.
An evolving technique used to treat inherited diseases. The medical procedure involves replacing, manipulating, or supplementing non-functional genes with healthy genes, in order to affect their function. [ Talking Glossary
Treatment that alters genes (the basic units of heredity found in all cells in the body). In early studies of gene therapy for cancer, researchers are trying to improve the body's natural ability to fight the disease or to make the tumor more sensitive to other kinds of therapy.
The correction of a genetic deficiency in a cell by the addition of new DNA and its insertion into the genome.
Treatment based on alteration of genetic material.
A treatment that involves "fixing" a faulty gene so that it behaves normally.
the introduction of a gene into a cell for the purpose of correcting a hereditary disease
A potential method of treatment for genetic disorders by the addition or substitution of a normal gene. Only gene therapy on non-reproductive cells is allowed in humans so the changes cannot be passed on to following generations. search for Gene therapy
An experimental procedure aimed at replacing, manipulating, or supplementing nonfunctional or misfunctioning genes with healthy genes. See also: gene, inherit, somatic cell gene therapy, germ line gene therapy
approach to treat, cure, or ultimately prevent disease by replacing, manipulating, or supplementing nonfunctional genes through the use of recombinant DNA technology
see germ line gene therapy and somatic cell gene therapy. Gene therapy of either kind should be clearly distinguished from the use of genomics to discover new targets for drug discovery and new diagnostic tools.
the treatment of disease by the deliberate alteration of the genetic material of the body's cells
Gene therapy is the insertion of genes into an individual's cells and tissues to treat a disease, and hereditary diseases in particular. Gene therapy typically aims to supplement a defective mutant allele with a functional one. Although the technology is still in its infancy, it has been used with some success.