A phagocytic tissue cell of the mononuclear phagocyte system that may be fixed or freely motile, is derived from a monocyte, and functions in the protection of the body against infection and noxious substances; the aveolar Macrophage can be found in lung and can be obtained in lung lavage, responsible for clearance of inhaled particles and lung surfactant.
a large, phagocytic, mononuclear lymphocyte found in tissues but derived from blood monocytes. Depending on the tissue they are locating in, macrophages are called histiocytes (connective tissue macrophages), Kupffer's cells (liver macrophages), or alveolar macrophages (lungs). Involved in the immune response to antigens, the macrophages process antigens and present them to the lymphocytes.
Found especially in areas where inflammatory processes are in progress. A scavenger cell. Occurs in cells of blood vessels and loose connective tissue. Mobil white cells in the blood that infiltrate into damaged tissue. They speed up the process of demyelination. Myelin breakdown occurrs in the presence of infiltrating macrophages.
Macrophage have specialized phagocytic capabilities including release of substances related to the immune response, anaphylaxis, and inflammation. Its main function is phagocytosis either as a clean-up operation or a defense activity.
A type of tissue cells that is derived from the blood monocyte. The monocyte migrates from the blood into tissues where it transforms into a macrophage. Macrophages are present in most tissues. The cell takes many forms and has several functions. Three examples of macrophage functions are 1) ingest and degrade debris during tissue repair and remodeling, 2) ingest and kill or contain the growth of microorganisms, and 3) process and present antigens to lymphocytes.
A lymphocyte that has left the circulation and settled and matured in a tissue. Because of their placement in the lymphoid tissues, macrophages serve as the major scavenger of the blood, clearing it of abnormal or old cells and cellular debris as well as pathogenic organisms.
A type of large immune cell that devours invading pathogens and other intruders. Macrophages stimulate other immune cells by "presenting" them with small pieces of the invaders. Macrophages also can harbor large quantities of HIV without being killed, and may therefore act as viral reservoirs.
Immune cell that envelops and digests incoming pathogens by the process of phagocytosis; the major cellular constituent of the mucosal defense system; macrophages also interact with lymphocytes to facilitate antibody production.
Any large cell with the ability to engulf other cells, generally found in the walls of the blood vessels. They are usually immobile but when stimulated by inflammation they become actively mobile and move throughout the body.
phagocyte residing in tissues throughout the body. In addition to ingesting foreign particles and microorganisms, macrophages synthesize proteins and other substances important in inflammatory responses, including cytokines. Macrophages that reside in the liver are called Kupffer cells.
A scavenger cell specializing in the ingestion and processing of AWTxtBold particulate matter, especially harmful bacteria. Macrophages are susceptible to infection by HIV and may serve as reservoirs for HIV.
A scavenger cell involved in demyelination. - Cells that have the ability to recognize and ingest all foreign antigens through rcceptors on the surface of their cell membranes. - A white blood cell with scavenger characteristics that has the ability to ingest and destroy foreign substances such as bacteria and cell debris.
a mature form of immune system cells released from the bone marrow. In simple terms they are the garbage collectors of the body, they also carry signal of infection to the T-cells and B-cells which then produce the appropriate antigen (a substance, usually a protein that induces the formation of defending antibodies) they are the intermediary between the innate and acquired immunity.
Type of large leukocyte (white blood cell) that uses a process called phagocytosis to eat bacteria and digest cellular debris; during inflammation, develops the ability to produce inflammatory molecules
A type of immune cell found in the body's tissues and organs. Macrophages rid the body of worn-out cells and other debris, secrete powerful antigen-destroying chemicals, and play an important role in activating T cells.
An immune cell that is among the first line of defence against invaders; also acts as antigen presenting cells. Macrophages are called different names depending where they are found in the body (e.g. microglial cells in the brain).
A phagocyte with one nucleus which is derived from a monocyte and which is found in tissue. It may be fixed or freely moving. It protects against infection and noxious substances. Its previous names are many and varied, usually depending on the type of tissue that it was isolated in.
A large immune cell that devours infectious material and other foreign invaders, as well as stimulating other immune cells. Macrophages can harbour large quantities of HIV without being killed, acting as reservoirs of the virus. Click here to return to list
A cell characterized by prominent lysosomes and the ability to phagocytose foreign material. Macrophages are involved in both non-specific immunity, due to the phagocytosis of foreign materials, and in specific immunity, due to the presentation of the ant
A large white blood cell, found primarily in the bloodstream and connective tissue, that helps the body fight off infections by ingesting the disease-causing organism. HIV can infect and kill macrophages.
a large scavenger cell that ingests degenerated cells and foreign organisms. Macrophages exist in large numbers throughout the body and contribute to the development of acquired immunity by acting as ANTIGEN PRESENTING CELLS. They also ingest and destroy foreign matter coated with ANTIBODIES. Macrophages can be infected by HIV.
A specialized white blood cell of central importance to the body; it ingests cellular debris and foreign material, destroys ingested microorganisms, processes ingested antigens as an initial step in the induction of a specific immune response, and synthesizes a number of important enzymes, coagulation factors, and messenger molecules; also referred to as a mononuclear phagocyte.
a large scavenger white blood cell that ingests and processes degenerated cells and foreign invaders. Macrophages secrete messenger proteins (monokines) involved in a variety of immune system responses. Macrophages are derived from monocytes that leave the blood to migrate into the tissues. Specialized macrophages protect the skin, lungs (alveolar macrophages), brain (microglia), liver (Kupffer cells), and other tissues. The long-lived macrophages are reservoirs of HIV.
A macrophage is a large scavenger cell present in connective tissue and many major organs and tissues including the bone marrow, spleen, lymph nodes, liver and the central nervous system. Macrophages ingest bacteria and cell debris and are responsible for the breakdown of worn-out red blood cells.
A large immune cell that devours invading pathogens and other intruders. Stimulates other immune cells by presenting them with small pieces of the invader. Macrophages can harbor large quantities of HIV without being killed, acting as reservoirs of the virus.
A large scavenger immune cell that ingests degenerated cells, blood tissue and foreign particles, and secretes messenger proteins (monokines) involved in inflammatory reactions, lymphocyte activation and acute systemic immune responses.
Macrophages (Greek: "big eaters", makros = large, phagein = eat) are cells within the tissues that originate from specific white blood cells called monocytes. Monocytes and macrophages are phagocytes, acting in both nonspecific defence (or innate immunity) as well as specific defense (or cell-mediated immunity) of vertebrate animals. Their role is to phagocytize (engulf and then digest) cellular debris and pathogens either as stationary or mobile cells, and to stimulate lymphocytes and other immune cells to respond to the pathogen.