Related family of proteins produced by many mammalian cell types that mediate chemotaxis and organize activities of cells of specfic and non-specific defenses (Lecture: Innate Immunity and Inflammation II, 2/21/02)
chemokines are signaling molecules that attract immune cells to infected cells. Some examples of chemokines are MIP-1a, MIP-1b,and RANTES. Chemokines have been found to bind to a corecptor for the HIVvirus that is on the surface of macrophages.
A large family of structurally homologous, low molecular weight cytokines that stimulate leukocyte movement and regulate the migration of leukocytes from the blood to tissues (1).
a group of specific chemotactic polypeptides all of which have a similar structure (4-cystein structure), involved in the migration and activation of cells, especially phagocytic cells and lymphocytes. They have a central role in inflammatory responses.
Also called beta chemokines. Studies of the relationship between HIV and these immune system chemicals have shown the complex exchange that take place when HIV and white blood cells meet.
One of a large group of proteins that act as lures and were first found attracting white blood cells. The chemokines are involved in a wide variety of processes including acute and chronic types of inflammation, infectious diseases, and cancer. The first chemokine to be identified was interleukin-8 (IL-8). Other chemokines include platelet factor 4, platelet basic protein, melanoma growth stimulatory protein, macrophage inflammatory protein 2, RANTES, MIP-1α, and MIP-1β.
Proteins produced by many human cells including endothelial cells, macrophages and cells of the immune system.
Soluble proteins produced and released by a wide variety of cell types during the initial phase of the body's response to injury, allergens, antigens, or invading microorganisms.
A large group of cytokines, falling into four separate families. The main families are the CC group and the CXC group. They include IL-8, MCP-1, RANTES, MIP-1α, MIP-1β, IP-10 and many others. They act on 7 transmembrane pass receptors and have a variety of chemotactic and cell-activating properties, acting on selected populations of target cells.
