A cell that is derived from the antigen-induced activation and maturation of B lymphocytes. It is the principal antibody producing form of B cells. In myeloma, the tumor cell has the appearance of plasma cells, that is, they are malignant plasma cells, sometimes referred to as myeloma
A lymphocyte-like cell with an eccentrically placed deep-staining nucleus. The nuclear chromatin is distributed in a "wheel-spoke" fashion. The cytoplasm is deep blue with a lighter halo about the nucleus.
Type of cell normally present in the body. It is responsible for making antibodies(immunoglobulins) that fight infection and help destroy cancer cells. When the immune system loses control over the plasma cell, it becomes cancerous. Thus, the term plasma cell dyscrasia.
The malignant cell in myeloma. Normal plasma cells produce antibodies to fight infection. In myeloma, the malignant plasma cells produce large amounts of abnormal antibodies which lack the capability to fight infection. The abnormal antibodies are the monoclonal protein, or M-protein. Plasma cells also produce other chemicals which can result in organ and tissue damage (i.e. anaemia, kidney damage and nerve damage).
Particular kind of lymph cells. Normal plasma cells produce antibodies against foreign pathogens such as infection pathogens. With multiple myeloma/plasmacytoma, there is unhindered multiplication of sick plasma cells that produce atypical and ineffective antibodies.
Plasma cells (also called plasma B cells or plasmocytes) are cells of the immune system that secrete large amounts of antibodies. They differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen presenting cell (APC), consuming an offending pathogen.