Cluster of differentiation (CD) marker protein expressed on cell surface.
Another name for a "helper" T-cell.
A symbol for glycoprotein expressed on the surface of most phytocytes and some lymphocytes, including Helper T cells. Human CD4 is the receptor that serves as a docking site for HIV viruses on certain lymphocyte cells. Binding of the viral glycoprotein gp120 to CD4 is the first step in viral entry, leading to the fusion of viral and cell membrane.
A molecule on the surface of some cells onto which HIV can bind. This cell overseas the action of the immune system. The HIV virus infects the CD4 cells and they are destroyed, or they do not work properly. It is used as a marker of disease progression.
The proportion of lymphocytes, a type of white blood cell that fights infection, that are CD4 cells (also known as T4-cells). If above 25% a child is considered to have no immunosuppression (able to fight infection). A CD4% between 15% and 24% is considered moderate immunosuppression (some possible problem with fighting infection). CD4% below 15% is considered severe immune suppression (potentially serious problems fighting infection).
a group of lymphocytes which are important in mediating the immune response; counting CD4 cell provides a guide to the potential for mounting an immune response to foreign substances and organisms.
antigen of T-helper lymphocytes
A glycoprotein predominantly found on the surface of helper T cells. In humans, it is a receptor for HIV, enabling the virus to gain entry into its host. A cell bearing the CD4 surface receptor.
A type of T cell involved in protecting against viral, fungal, and protozoal infections. These cells normally orchestrate the immune response, signaling other cells in the immune system to perform their special functions. Also known as T helper cells. HIV's preferred targets. Destruction of CD4+ cells is the major cause of the immunodeficiency observed in AIDS. Lab work is done at specific intervals to measure the number of CD4 cells in circulation.
A protein on the surface of the T-cell which acts as the receptor for the viral envelope protein gp120.
A protein receptor embedded in the cell surface of T-lymphocytes, monocytes/macrophages, Langerhans cells, astrocytes, keratinocytes, and glial cells. HIV invades cells by first attaching to the CD4 receptor molecules.
A specific, genetically determined type of T-cell, that is thought to play a primary role in MS & EAE. It is also known as "a helper T-cell".
T cell - also known as a “helper†cell, a cell of the immune system that helps other immune system cells produce antibodies. CD4+ T cells are the cell type that are infected and destroyed by HIV.
Related Topic"... White blood cells are composed primarily of neutrophils, monocytes and lymphocytes..."
The protein structure on the surface of a human cell that allows HIV to attach, enter, and consequently infect a cell. CD4 receptors are present on CD4 lymphocytes (helper T cells), macrophages and dendritic cells, among others. Normally, CD4 acts as an accessory molecule, forming part of larger structures (such as the T cell receptor) through which T cells and other cells signal each other.
a membrane protein of helper T cells that interacts with membrane proteins of HIV
Cluster of differentiation marker of helper T-cell; levels of T-cells are used to determine stage of immunocompromised state.
A molecule on the surface of some cells onto which HIV can bind. The CD4 cell count roughly reflects the state of the immune system.
a protein embedded in the surface of some T-cells and certain other cells (e.g., macrophages, Langerhans cells, glial cells). HIV invades cells by attaching to their CD4 receptor.
the cell surface protein CD4 is important for recognition by the T cell receptor of antigenic peptides bound to MHC class II molecules. It acts as a co-receptor by binding to the lateral face of MHC class II molecules.
A type of protein molecule in human blood that is present on the surface of 65% of human T cells. CD4 is a receptor for the HIV virus. When the HIV virus infects cells with CD4 surface proteins, it depletes the number of T cells, B cells, natural killer cells, and monocytes in the patient's blood. Most of the damage to an AIDS patient's immune system is done by the virus' destruction of CD4+ lymphocytes. CD4 is sometimes called the T4 antigen.
A type of protein molecule in human blood, sometimes called the T4 antigen, that is present on the surface of 65% of immune cells. The HIV virus infects cells with CD4 surface proteins, and as a result, depletes the number of T cells, B cells, natural killer cells, and monocytes in the patient's blood. Most of the damage to an AIDS patient's immune system is done by the virus' destruction of CD4+ lymphocytes.
A protein structure on the surface of cells of the immune system; HIV enters the cell by attaching itself to the CD4+ receptors. Once inside the cell, HIV begins to replicate itself, and over time renders the immune system defenseless.
a T-cell signalling/co-receptor molecule involved in MHC-II adhesion
The protein imbedded on the surface of T-helper cells to which HIV attaches itself and through which it first enters the cells.
a protein on the surface of T cells and other cells, functioning as a receptor for the aids virus antigen.
a receptor antigen on the T-4 helper surface
Related Topic"...T-cells (CD3 cells) are divided into T-helper (CD4 cells) and T-suppressor/ cytotoxic (CD8 cells) cells..."
Related Topic"...Human CD4 is the receptor that serves as a docking site for HIV viruses on certain lymphocyte cells..."
CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR). It amplifies the signal generated by the TCR by recruiting the tyrosine kinase lck that is essential for activating many molecules involved in the signaling cascade of an activated T cell.