Therapy given before the primary surgical treatment in order to shrink a tumor.

The use of a different kind of therapy before the use of what is considered a more definitive therapy, e.g. the use of  neoadjuvant androgen deprivation therapy (ADT) prior to radiation therapy of PC or the use of neoadjuvant chemotherapy before surgery  for breast cancer. Neoadjuvant is contrasted to adjuvant, which relates to the use of another therapy after the so-called more definitive therapy, e.g. ADT after RT

Initial treatment which is not the primary therapy (for instance, chemotherapy or radiation, prior to surgery). It is often administered in instances of locally advanced disease in the hope that the size of the tumor is reduced in order that it might be surgically removed.

A new method that assists in the prevention or cure of disease