A molecular indicator of environmental exposure (used in toxicology), disease (used as a diagnostic tool), or susceptibility to disease.
(Biomarqueur) Biological reactions of organisms exposed to a pollutant, by which qualitative and/or quantitative assessments may be made if the contaminant concentration in water reaches a level or begins to be manifested in clandestine effects on the toxicity of the sensitive populations so exposed.(Translated from Ramade, F. Dictionnaire encyclopédique de l'écologie et des sciences de l'environnement. Édiscience international, Paris, 1993.)
A distinctive biological or biologically derived indicator (as a biochemical metabolite in the body) of a process, event, or condition (as aging or exposure to a toxic substance) used to measure or indicate the effects or progress of a disease, illness, or condition.
A molecular indicator of a specific biological property; a biochemical feature or facet that can be used to measure the progress of disease or the effects of treatment.
a physiological measure used to indicate a toxic event in an animal
Indicator (molecular, biochemical, cellular or organism) signalling an event or condition in a biological system or sample and giving a measure of exposure to, effect of, or susceptibility to, a xenobiotic. (after Duffus, 1993)
any measurable sign (including visual and molecular) indicating the status of an organisms physiology, health, etc. that can be used in the diagnosis of a disease or syndrome4; includes a variety of measures of specific molecular, cellular, and physiological responses of key species to either contaminant exposure or poor health5.
Any consistently detectable biological molecule that is associated with a biological state, such as a disease.
A biomarker is any biomolecule that is associated with a particular pathological or physiological state. Protein biomarkers are often used to identify drug targets or to diagnose and monitor therapy.
A molecular indicator of a specific biological property or function. Biomarker levels can be measured to detect or monitor the course of disease or assess the effects of treatment.
1. Indicator signaling an event or condition in a biological system or sample and giving a measure of exposure, effect, or susceptibility. As related to biomonitoring, a biomarker is the presence of any substance, or a change in any biological structure or process that can be measured as a result of exposure. Many biomonitoring studies focus on chemical substances or their metabolites as biomarkers. 2. Parameter that can be used to identify and effect in an individual organism and can be used in extrapolation between species for risk assessment.
An objective, measurable biochemical parameter that faithfully reflects a critical pathway to a disease or a critical pathway that predisposes to a disease (ultimate or proximal critical pathways).
a biological measure of an organism's response to a contaminant
a biological parameter (gene, metabolite or protein) that is indicative of a physiological or pathological state
a certain biological element that undergoes change when exposed to a stressor, such as chemical contamination
a change in a biological system that can be related to an exposure to, or effect from, a specific xenobiotic or type of toxic material
a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathological processes or pharmacologic responses to a therapeutic intervention
a characteristic that is objectively measured and evaluated as an indicator of normal biologic or pathogenic processes or pharmacological responses to a therapeutic intervention
a laboratory-derived, cellular or molecular indicator of exposure, health effect, or susceptibility
a measurable alteration in biological samples, such as cells
a measurable event occurring in a biological system, such as the human body
a measurement of a variable related to a disease that may serve as an indicator or predictor of that disease
an indicator of a biological process or event, such as aging, poisoning or, in this case, blood vessel growth
an indicator of a disease process, and could replace hard clinical end points as a measure of the effect of new therapies
a parameter which can be evaluated quantitatively, semi-quantitatively or qualitatively, and which provides information on exposure to a xenobiotic, or on the actual or potential effects of that exposure in an individual or in a group
a xenobiotically induced variation in cellular or biochemical components or processes, structures, or functions, that is measurable in a biological system or sample
A distinctive usually biochemical indicator of a biological or geochemical process or event
observable change (not necessarily pathological) in the function of an organism, related to a specific exposure or event.
a test that reflects biological activity of an illness. Some biomarkers are static, like a HLA DR genotype. Others are called dynamic, in that they change with disease activity
A biological indicator that signals certain stresses or diseases in the body and gives a measure of exposure, effect, or susceptibility.
an indicator, usually of a disease or a risk for a disease. For example, blood cholesterol is a biomarker for a risk for heart disease.
A specific, observable physical trait used to measure or indicate the effects or progress of a disease or condition.
A specific biochemical in the body which has a particular molecular feature that makes it useful for measuring the progress of disease or the effects of treatment.
Used to indicate or measure a biological process; for example, levels of a specific protein in blood or spinal fluid. Detecting biomarkers specific to a disease can aid in the identification, diagnosis, and treatment of affected individuals, as well as people who may be at risk but who do not yet have symptoms.
A chemical, biochemical, or functional indicator of exposure to (or the effect of exposure to) - an environmental chemical, physical or biological agent.
Parameter that can be used to identify a toxic effect in an individual organism and can be used in extrapolation between species. Indicator signalling an event or condition in a biological system or sample and giving a measure of exposure, effect, or susceptibility.
a physical, functional, or biochemical indicator (e.g., the presence of a particular metabolite) of a physiological or disease process.
A specific biological trait, such as the level of a certain molecule in the body, that can be measured to indicate the progression of a disease or condition.
A molecular marker that is associated with or identifies biological function.
any parameter that can be used to measure an interaction between a biological system and an environment agent, which may be chemical, physical or biological (WHO 1993).
Used to indicate or measure a biological process (for instance, levels of a specific protein in blood or spinal fluid, genetic mutations, or brain abnormalities observed in a PET scan or other imaging test). Detecting biomarkers specific to a disease can aid in the identification, diagnosis, and treatment of affected individuals and people who may be at risk but do not yet exhibit symptoms.
measure that is an indicator of a normal physiologic process, or a pathologic state or the response of an organism to an intervention that can be used in clinical research. When a biomarker can replace a clinical endpoint it is called a surrogate endpoint.
In medicine, a biomarker is an indicator of a particular disease state or a particular state of an organism.