The Condition"...The substance is harmless in itself, but high levels of these pyrrolles systemically bind with B6 and zinc, preventing the use of these essential nutrients in the brain and body..." Related Topic"This condition is caused by an overproduction during hemoglobin synthesis of kryptopyrrole, which chemically combines with vitamin B6 and zinc, resulting in their excretion and a severe deficiency of both of these essential nutrients..." Relationship to Zinc Requirement"Pyroluria is caused by an overproduction of kryptopyrrole during hemoglobin synthesis, which chemically combines with vitamin B6 and zinc, resulting in their excretion and a deficiency of both of these essential nutrients..." Recommendation Zinc"...The resulting molecule then chelates zinc, the combined product appearing in the urine..." Recommendation Vitamin B6 (Pyridoxine)"Pyrolurics commonly respond within a few months to B6, zinc and manganese..."
The Condition"...They tire easily, are anemic, have poor dream recall, prefer not to eat breakfast, notice upper abdominal pain when stressed, and experience a "stitch" in their side if they run..."
The Condition"...The substance is harmless in itself, but high levels of these pyrrolles systemically bind with B6 and zinc, preventing the use of these essential nutrients in the brain and body..." Related Topic"This condition is caused by an overproduction during hemoglobin synthesis of kryptopyrrole, which chemically combines with vitamin B6 and zinc, resulting in their excretion and a severe deficiency of both of these essential nutrients..." Relationship to Zinc Requirement"Pyroluria is caused by an overproduction of kryptopyrrole during hemoglobin synthesis, which chemically combines with vitamin B6 and zinc, resulting in their excretion and a deficiency of both of these essential nutrients..." Recommendation Vitamin B6 (Pyridoxine)"Pyrolurics commonly respond within a few months to B6, zinc and manganese..." Recommendation Zinc"Kryptopyrrole is a reacting agent which combines irreversibly with active vitamin B6..."
Relationship to Vitamin B6 Requirement"A functional pyridoxine deficiency is common in pyroluria (often seen in alcoholics), due not so much to inadequate intake as impaired conversion to its active form, pyridoxal-5-phosphate, and enhanced degradation..."
a genetically determined chemical imbalance involving an abnormality in hemoglobin synthesis
This condition is caused by an overproduction during hemoglobin synthesis of kryptopyrrole, which chemically combines with vitamin B6 and zinc, resulting in their excretion and a severe deficiency of both of these essential nutrients. Most pyroluric individuals never develop schizophrenia symptoms.
The Condition"...Pyroluria may occur along with other imbalances as seen in some subtypes of schizophrenia such as histapenia (low histamine), histadelia (high histamine), high copper levels or cerebral allergies..."
The Condition"...Supplementation with vitamin B6 until daily dream recall returns (a normal phenomenon) as well as with zinc and manganese needs to be continued daily..." Recommendation Vitamin B6 (Pyridoxine)"Pyrolurics commonly respond within a few months to B6, zinc and manganese..."
The Condition"...If additional antianxiety support is needed, GABA, tryptophan, chromium and inositol should be considered..."
Pyroluria, or malvaria (from the term mauve factor), is the presence of excess pyrroles (a group of chemical compounds) in the urine. It was initially described by Abram Hoffer, a pioneer in orthomolecular medicine and orthomolecular psychiatry. Carl Pfeiffer substantially extended Hoffer's work.Saul AW, Jolliffe M, Hoffer A, http://www.doctoryourself.com/biblio_pfeiffer_ed.html Bibliography of the Publications of CARL C.