Toxic action occurring among the heritable chromosomes. Heritable chromosomes can be transmitted from parent to offspring.

The ability to damage genetic material Half-life The time required for half the amount of a drug introduced into an animal to be metabolised or excreted.

The effect of a substance on cellular genetic structure, leading to possible abnormalities

The adverse health effect a chemical has on genes and chromosomes, primarily gene mutations, chromosome aberrations and changes in chromosome number. Genotoxicity may be indicative of cancer-causing chemicals.

effects on genetic material, an early screen for possible cancer-inducing activity

The ability of a material to cause damage to genes or chromosomes. Genotoxicity studies provide an early screen for possible cancer-inducing activity.