Mediators of various allergic and inflammatory reactions produced by the lipoxygenase pathway in leukocytes, mast cells, platelets and in the lungs.
Compounds that act as modulators of allergic and inflammatory reactions.
Natural substance produced by certain cells within the body as part of the inflammatory reaction to an irritant (asthma trigger.) In asthmatics, leukotrienes and their receptors cause the muscles in the airways to tighten and mucus to be produced. This mucus can block the smaller airways, which can result in coughing, wheezing, and breathing problems. Anti-leukotriene drugs get in the way of this process and may provide preventive relief in some asthmatics.
Substances produced by mast cells during an allergic reaction. They contribute to most of the features of allergic reactions and cause bronchial constriction in asthma
complex group of extremely powerful biological regulators, produced from 20 carbon precursors, initially by the action of the lipoxygenase enzymes.
Substances released from various cells in the body that can cause airway inflammation and contraction of the muscles surrounding the airways in the lungs.
Chemicals released during an allergic reaction that cause allergy symptoms.
have a role in allergic or inflammatory reactions.
lipid molecules that are synthesized from arachidonic acid by the lipoxygenase pathway and function as local hormones, primarily to promote inflammatory and allergic reactions.
A group of chemical mediators of inflammation that stimulate the constriction of smooth muscle in the bronchioles.
A collection of metabolites of arachidonic acid which have powerful pharmacological effects.
Vasoactive substances, whose synthesis from arachidonic acid involves lipoxygenase in leucocytes; important mediators of inflammatory response.
Chemicals responsible for inflammation of the airways in diseases such as asthma (see Allergies).
