Definitions for "Cross-Resistance"
the development of resistance to one agent (e.g., drug) which also confers resistance to another (often similar) agent.
resistance of HIV to two or more drugs.
Resistance of a virus to more than one drug of the same class, e.g. HIV resistance to certain protease inhibitors may result in a PWA being unable to benefit from other protease inhibitors. HIV resistance to any one of the three current non-nucleoside RT inhibitors has been shown to rule out the clinical use of any of the others in most cases.