Definitions for "Monoclonal Antibodies"
Related Terms:
Monoclonal antibody, Major histocompatibility complex, Mhc, Epitope, Immunoglobulin, Complement, Antibody, Immunoglobulins, Antibodies, Interferons, Antigen-presenting cell, Complement system, Interleukin-2, Interferon, Gamma globulin, Antigenic determinant, Hybridoma, Humoral immunity, Antigen processing, Igg, Polyclonal antibody, Interleukin-1, Immune system, Innate immunity, Immunoglobulin g, Biologic response modifiers, Immune globulin, Hapten, Autoantibodies, Immunotoxin, Antibody-mediated immunity, Memory cell, Polyclonal, Superantigen, Cell-mediated immunity, Antigen, Igm, Alpha interferon, Opsonization, Cellular immunity, T-cell receptor, Interleukins, Immune response, Immune complex, Immunomodulator, Immunocompetent, Dna vaccine, Biologic therapy, Antiserum, Biological response modifiers
Single antibodies that can be made in the laboratory and used for targeted cancer treatment. This type of treatment is experimental.
substances that can locate and bind to cancer cells regardless of their location in the body
antibodies derived from a single clone of cells and directed against a particular antigen.
Antibodies that are specific to certain types of cancer.
antibodies artificially produced in tissue culture which may be tailor-made to combat disease.
laboratory-produced molecules that can be directed to "lock on" to specific cells, parts of cells, or other molecules, either to identify them for diagnostic purposes or to kill them in therapy. Monoclonal antibodies are still experimental in many instances.
an antibody that is produced in the laboratory so that it will react with only one specific foreign protein; used to help diagnose certain kinds of cancer
Artificially produced proteins of exceptional purity and specificity derived from hybrid cells capable of producing a continuous supply of identical antibodies. Like a key in a lock, antibodies lock in to particular antigens, or cell-surface identifying markers. Compared to "guided missiles."
Clone of cells sensitized to a specific antigen found on the surface of a tumor cell
antibodies made in the laboratory and designed to target specific substances called antigens. Monoclonal antibodies which have been attached to chemotherapy drugs or radioactive substances are being studied to see if they can seek out antigens unique to cancer cells and deliver these treatments directly to the cancer, thus killing the cancer cells without harming healthy tissue. Monoclonal antibodies are also used in other ways, for example, to help find and classify cancer cells.
Antibodies made by cells belonging to a single clone. These highly specific antibodies can be produced in the laboratory. They are very important reagents for identifying and classifying disease by immunophenotyping cells. They have clinical applications for targeted delivery of drugs to leukemia or lymphoma cells and can be used to purify cells used for stem cell transplants.
Antibodies which can be traced back to one single originator cell and which bind specifically to one particular foreign substance (antigen). They are produced with the help of hybridoma cells.
Antibodies specific for a single antigen. They can be produced in large quantities in the laboratory. Monoclonal antibodies are being studied in clinical trials to determine their effectiveness in cancer detection, diagnosis, and treatment.
Antibodies produced by genetically identical cells under laboratory conditions.
A collection of identical antibodies that recognizes the same single epitope.
Are laboratory-produced antibodies, which can be programmed to react againsta specific antigen in order to suppress the immune response.
("MAb") are antibodies secreted by a hybridoma clone, each such clone being derived from a single B cell (lymphocyte) that produces a specific antibody.
Laboratory-produced antibodies, which can be programmed to react against a specific antigen in order to suppress the immune response.
Antibodies designed to seek out chosen targets on cancer cells; they are under study to deliver chemotherapy and radiotherapy directly to a cancer, thus killing the cancer cells and sparing healthy tissue.
Proteins produced by the immune system, which can be synthesized in the laboratory in pure form by a single clone (population) of cells.
Antibodies derived from a single source (a group of cloned cells) and recognize only one kind of antigen. They are made in the laboratory from hybridoma cells, hybrids of antibody-producing cells and immortal cancer cells.
Antibodies produced in a laboratory that act against specific infectious agents, toxic inflammatory substances or cancer cells.
Identical antibodies that are made in large amounts in the laboratory.
Laboratory-produced identical antibodies that can target a specific antigen.
Biologic response modifiers. Chemicals or radiation is tagged to the MAB and delivered directly to the tumor cells. Or the MAB itself might be capable of tumor cell destruction.
A form of biological therapy that may help the body's own immune system fight cancer by locating cancer cells and either killing them or delivering cancer-killing substances to them without harming normal cells.
Artificially manufactured antibodies specifically designed to find targets on cancer cells for diagnostic or treatment purposes.
Families of identical antibodies produced in the laboratory to target a specific protein.
Artificially produced antibodies used in research and also for treatment of some diseases. They are produced in a cell culture (clone) by multiplying one single mother cell thus having exactly the same properties (very pure antibody).
(MAbs) are antibodies that are genetically engineered and custom-designed to bind specifically to a particular antigen and destroy it. When used as a therapeutic agent, monoclonal antibodies generally work quickly, for a significant amount of time, with minimal side effects.
Antibodies designed to seek out chosen targets on cancer cells. Researchers are studying the ability of these antibodies to deliver chemotherapy and radiotherapy directly to a cancer, thus killing the cancer cell and sparing healthy tissue. Studies are also underway to determine if monoclonal antibodies can be produced to detect and diagnose cancer cells at a very early, curable stage.
(MAbs) – A highly specific antibody produced in large quantities by clones of an artificially created cell.
A type of drug that can locate and bind to cancer cells.
proteins that stick to the surface of cells and can mark them for killing by the body’s immune system.
Substances that can locate and bind to cancer cells wherever they are in the body.
Protein produced by the white blood cells to destroy a virus or other intruder that enters the body.
antibodies produced by a single clone and which are homogeneous (identical in form).
Antibodies produced in the laboratory by a hybridoma or antibody-producing cell source for a specific antigen. Monoclonal antibodies are useful as tools for identifying specific protein molecules.
(mon-o-klone'al an'ti-bod-eez)- One of several new substances used in biological therapy. These antibodies, all exactly alike, are mass-produced and designed to home in on target cancer cells. Monoclonal antibodies are products of new scientific techniques and may prove useful in both cancer diagnosis and treatment.
Structurally identical antibodies that recognise only one kind of antigen (a large molecule or small organism whose entry into the body provokes an immune system response)
Antibodies are proteins that help white blood cells fight off viruses and bacteria, by binding to foreign invaders and signaling the immune cells to attack. Monoclonal antibodies are antibodies that are made in the laboratory to bind to only one single type of molecule. They are currently being used to bind to tumor cells, either to signal to immune cells to attack, or to carry toxic agents directly to the tumor.
Antibodies which have been cloned artifically from a culture of cells in which all the cells derive from a single cloned cell. They produce antibodies with a single specificity that are, therefore, known as monoclonal antibodies.
using laboratory-produced substances that can locate and bind to cancer cells
Antibodies produced by a single cell or its identical progeny, specific for a given antigen. As a tool for binding to specific protein molecules, monoclonal antibodies are invaluable in research, medicine and industry.
antibodies made from single cells that recognize one chemical component on a foreign target molecule.
A biological response modifier with unique ‘homing device" properties. Chemicals or radiation tagged to the MAB may be delivered directly to tumor cells. Or, the MAB itself may be capable of tumor cell destruction.
Antibodies that recognize only one antigen and bind it specifically by recognizing part of its structure
Proteins produced in the laboratory that can find and bind to cells or other proteins. In CLL, monoclonal antibodies may be able to bind to the cancerous lymphocytes.
Antibodies produced by a hybridoma or antibody-producing cell source for a specific antigen. Monoclonal antibodies are useful as a tool for identifying specific protein molecules. See also Antibodies; Antigen; Hybridoma.
antibodies made in the lab,to lock onto specific antigens. Antigens are substances that can be recognized by the immune system. Monoclonal antibodies that have been attached to chemotherapy drugs or radioactive substances are being studied for their potential to seek out antigens unique to cancer cells and deliver the treatment directly to the cancer, thus killing the cancer cell and not harming healthy cells. Monoclonal antibodies are also often used to help detect and classify cancer cells under a microscope. Other studies are being done to see if radioactive atoms attached to monoclonal antibodies can be used in imaging tests to detect or locate small groups of cancer cells. See antibody, antigen, immunocytochemistry.
Proteins composed of laboratory-developed identical molecules used to treat disease. Also called genetically engineered antibodies.
1. Man-made (anthropogenic) clones of a molecule, produced in quantity for medical or research purposes. 2. Molecules of living organisms that selectively find and attach to other molecules to which their structure conforms exactly. This could also apply to equivalent activity by chemical molecules.
Monoclonal antibodies (mAb) are antibodies that are identical because they were produced by one type of immune cell and are all clones of a single parent cell. Given (almost) any substance, it is possible to create monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine.