Copies of antibodies that target diseased cells in the body with precision. Side effects may include allergic reactions, fevers, chills, low blood pressure, and liver and kidney problems. Used as drug delivery systems for cancer treatments.
antibodies created with biotechnology techniques in laboratories. MAbs are highly specific and "recognize" and target only one molecule, such as a receptor, or antigen.
a single, specific, pure antibody that can be produced in large quantities by fusing a myeloma cell or B lymphocyte tumor cell with an antibody producing cell of a desired specificity, usually a lymphoid cell; potentially useful in disease diagnosis and therapy.
Highly specific, purified antibody derived from only one subset of cells and which recognizes only one antigen or epitope.
Genetically engineered antibodies of identical molecular structure that recognize and bind to a single, specific cell-surface structure. Monoclonal antibodies are capable of selectively targeting specific cells, such as cancer cells, while bypassing most normal tissue. In therapeutic applications, they can be used alone, in combination with other therapies, or they can be used to deliver drugs, toxins or other payloads.
Antibody produced in the laboratory from a clone of hybridoma cells, each of which produces the same specific antibody.
an antibody produced by a single type of immune cell which binds to a specific part of its protein target
Antibodies that are all identical, derived from a single "clone". Sometimes used in "purging", a process by which certain cells are removed from bone marrow before infusion into patients
immunoglobulins derived from a single clone of plasma cells. Monoclonal antibodies constitute a pure population, as they are produced by a single clone in vitro and are chemically and structurally identical.
A pure antibody that recognizes only one epitope. It is isolated from a single B-cell and grown in cell culture.
Antibody secreted by a hybridoma clone. Because each such clone is derived from a single B cell, all of the antibody molecules it makes are identical.
Antibody produced by the progeny of a single B cell and thus a homogeneous protein exhibiting a single antigen specificity. Experimentally, it is produced by use of a hybridoma. ( Figure 6-10)
an antibody which is produced artificially from a cell clone. It consists of only one immunoglobulin, which comes from its parent lymphocytes.
(mah-no-clone-al an-teebaw-dee) Antibodies are substances produced by the immune system in response to foreign antigens, such as bacteria or viruses. Antibodies bind to the foreign antigen and help eliminate the antigen from the body. Monoclonal antibodies are a specific type of antibody, created in a lab that seeks out and adheres to a specific target in the body. AVASTIN is a monoclonal antibody that targets and binds to VEGF.
Highly specific protein that can bind to any single substance to register a presence or to deactivate it.
An antibody that recognizes only one type of antigen; sometimes used as immunotherapy to treat diseases such as cancer.
(mon-uh-KLOH-nul) Chemically and immunologically homogeneous antibodies produced by a single clone of antibody-secreting cells; a monoclonal antibody against glycoprotein IIb/IIIa is undergoing investigation as a platelet function inhibitor.
An artificially produced pure form of an antibody. Normally, an antigen will cause many different slightly different forms of antibody to be formed
an antibody produced in a laboratory which recognises one specific part of a specific micro-organism.
An antibody, produced by a hybridoma, directed against a single antigenic determinant of an antigen.
antibodies produced by a single cell or its identical progeny, specific for a given antigen. As a tool for binding to specific protein molecules, monoclonal antibodies are invaluable in research, medicine, and industry.
Chemically and immunologically homogeneous antibodies produced by hybridomas, which are formed by fusion of normal lymphocytes and tumor cells.
Type of man-made antibody that is used in the diagnosis and treatment of various diseases. All monoclonal antibodies of a specific type are identical to each other.
An antibody that is developed from a single cell. MAb therapies developed to treat cancer are specific and target the antigen on the tumor to kill the abnormal cell.
any of a class of antibodies produced in the laboratory by identical offspring of a hybridoma; very specific for a particular location in the body
a cloned copy of one or more of the antibodies made by the immune system in its effort to control HIV
a composition with a homogeneous antibody population
an antibody made in the lab
an antibody prepared in such a way that it reacts to a single antigen
an antibody produced by a single clone of B cells
an infection-fighting protein produced by the body's immune system that binds to a specific target to help destroy foreign invaders or toxins, such as cancer cells
a protein, made in the laboratory from a single copy of a human antibody
a protein manufactured in the laboratory which targets a single region in HIV
a protein produced from clones of a single antibody-producing cell (called monoclones)
a protein that fits like a lock and key with a protein on the cancer cell
a protein that is produced in a laboratory and is designed to locate certain components of cells within the body
a protein that is similar to the naturally occurring antibodies made normally by the immune system
a protein that reacts with a specific site on a cell
a protein that reacts with coumadin coumadin site or protein of a cell
a substance made in the laboratory that can bind to cancer cells
a type of antibody produced from a single cell
an artificially made antibody used against a specific antigen. Use of monoclonal antibodies is being researched to target chemotherapy or radioactive substances directly to cancer cells. More Information.
a monoclonal antibody is characterized by a defined sequence and structure of its variable regions and can specifically bind to one defined target (or antigen).
A type of antibody derived from hybridoma cells. These antibodies are of higher purity and specificity than polyclonals.
A specialized protein made in a laboratory to help the body’s immune system destroy cells that are harmful to the body.
An antibody that is made in large amounts in a laboratory and may be used to treat certain diseases.
Antibody directed to a single epitope on the target molecule
An antibody produced by a single clone of cells. Monocloned antibodies can be made in large amounts in the laboratory.
immunoglobulin, specific for a single antigenic determinant, produced in vitro by hybridomas (lymphocytes fused with tumor cells)
An antibody which specifically binds to the compound of interest.
Immune substance made in the laboratory that attacks cancer cells
Français] Highly specific purified antibody that was derived from only one clone of cells and recognizes only one antigen.
An antibody (a type of protein) designed by scientists to target one kind of cell, such as cells involved in cancer or other diseases. Monoclonal antibodies may be made of mouse proteins, by combining human and mouse proteins, or by using only human proteins.
a form of biologic therapy. Each monoclonal antibody acts specifically against a particular antigen.
Pronunciation: (MAH-no-KLO-nul AN-tih-BAH-dee) A laboratory-produced substance that can locate and bind to specific proteins that reside on the surface of breast cancer cells. Monoclonal antibodies can be used alone to identify abnormal cells and stimulate the immune system, or they can be used to deliver medications, toxins, or radioactive material directly to a breast tumor. For example, trastuzumab (brand name: Herceptin) is one monoclonal antibody that targets the HER2/neu protein on the surface of certain kinds of breast cancer cells.
A highly specific, purified antibody that is derived from only one close of cells and recognizes only one antigen. uscle Flexion Muscles tend to be kept flexed.
A type of antibody that is created in the laboratory.
An antibody that recognises a specific epitope, or region, of a foreign substance.
A monospecific immunoglobulin produced by a single clone of cells.
Monoclonal antibodies are a type of biological therapy produced in the laboratory. In ITP and macroglobuliemia, monoclonal antibodies are used to decrease the number of cells producing inappropriate antibodies.
Highly specific, purified antibody that is derived from only one clone of cells and recognizes only one antigen. See also Hybridoma; Myeloma.
An antibody made to target antigens on cancer cells and eliminate them without harming healthy tissue
an ANTIBODY produced by laboratory cultures of a single CELL LINE. The antibodies are all identical, binding with the same EPITOPE.
custom-made, identical antibody that recognizes only one epitope.
an antibody that recognizes a single target. Polyclonal antibodies recognize several related targets.
An antibody produced in the laboratory that can target specific antigens (substances that provoke in immune response). They can be made in large quantities and are being tested for their use in cancer diagnosis and treatment.
Homogeneous antibody originating from a single clone, produced by hybridoma cell
An antibody that is directed against one specific protein (antigen).
an antibody with a single specificity produced by an immortal B cell line
Antibody produced by cloned cells derived from a single lymphocyte BT antibody RT polyclonal antibody
A monoclonal antibody is an antibody that is produced artificially from a single cell clone and therefore consists of a single type of immunoglobulin. For example, monoclonal antibodies are produced by fusing antibody-forming lymphocytes from mouse spleen with mouse myeloma cells. The resulting hybrid cells, called hybridoma, multiply rapidly (like cancer cells) and produce the same antibody as their parents.
An antibody derived from a single cell in large quantities for use against a specific protein.
an antibody produced by means of recombinant DNA technology to recognise one specific substance
An antibody produced in a laboratory from a single clone that recognizes only one antigen.
A single type of antibody that is directed against a specific epitope and is produced by a single clone of B cells or a single hybridoma cell line, which is formed by the fusion of a lymphocyte cell with a myeloma cell.
The unique immunoglobulin molecule (antibody) produced by a clone of cells derived from a fusion of a B lymphocyte with a myeloma cell.
Immumochemically identical antibodies produced by a clone of plasma cells. Monoclonal antibodies are now being produced commercially using hybridomas.
a substance, normally a protein, which can be synthesized in the laboratory in pure form from a single population of cells. These antibodies (protein molecules sent out as the primary immune defense) have an affinity for antigens found on the surface of cells and those that are malignant.
Laboratory-produced substance that can locate and bind to cancer cells wherever they are in the body. Many monoclonal antibodies are used in cancer detection or therapy; each one recognizes a different protein on certain cancer cells. Monoclonal antibodies can be used alone, or they can be used to deliver drugs, toxins, or radioactive material directly to a tumor.
is a specific antibody produced in large quantity by the clones of a single hybrid cell formed in the laboratory by the fusion of a B cell with a tumor cell. The resulting hybrid cell, or hybridoma, multiplies rapidly, creating a clone that produces large quantities of the antibody.
A protein that recognizes and attacks one specific foreign substance invading the body (antigen). A monoclonal antibody may be used for early disease diagnosis and therapy. See fusion. monoculture - Producing only one type of crop over a large area of farmland.
An antibody that is developed in the laboratory from a single cell. MAb therapies to treat cancer target the antigen on the tumor. They kill the abnormal cell but also kill normal cells that express the same antigen.
a type of antibody, produced in a laboratory, which seeks out and attaches to foreign bodies, such as cancer cells.
A monoclonal antibody is an antibody produced by a single population of cells (hybridoma); it recognises and binds a single part (epitope) of an antigen.
