protein that detects and repairs gene damage, coordinating events that cause the cell to stop its growth and repair the damage. If the damage is too great, p53 becomes the catalyst directing the damaged cell to commit suicide.
A protein with complex functions that include mediating cell cycle arrest after DNA damage. Li-Fraumeni syndrome (which results in a marked increase in the risk of breast cancer) is associated with inherited mutations of the p53 gene. The majority of p53 mutations result in an abnormal protein which accumulates in cells and is thus easily identified immunohistochemically. Acquired (somatic) mutations are found in approximately 50% of breast cancers.
A 53KDa protein the product of a tumour suppressor gene. The loss of this protein due to mutation is a primary event in the formation of many types of cancer (breast, colon, lung, leukaemia, liver). P53 is involved in regulating the activity of some other genes (eg. P21, a cell division kinase inhibitor). It also prevents cells entering cell division. P53 levels are increased after DNA is damaged by UV and ionizing radiation and cells are arrested in cell division until either the damage is repaired or they die by apoptosis (programmed cell death).
A gene, which encodes a protein that regulates cell growth and is able to cause potentially cancerous cells to destroy themselves.
one of the tumor suppressor genes. Changes of these and similar genes may also be responsible for making some prostate cancers more likely to grow and spread more rapidly than others.
An anti-oncogene that normally inhibits the growth of tumors; it can prevent or slow the spread of cancer. p53 acts as a checkpoint in the cell cycle, regulating cell growth and division. Mutations in p53 are responsible in part for about 50% of human cancers.
A gene in the cell that normally inhibits the growth of tumors, which can prevent or slow the spread of cancer.
A gene responsible for regulating the growth cycle of a cell. A mutation to this gene can cause certain types of cancer.
A suppressor gene. Certain genetic mutations in p53 cause li-fraumeni syndrome. Source : PhRMA Genomics
an important tumour suppressor gene that prevents replication of damaged DNA by normal cells and promotes their apoptosis
gene found in every cell in your body. It tells the cell's machinery how to make a protein, also called p53. This protein has several roles in a normal cell, the most important of which is to stop cells dividing if they become damaged - it is a tumour suppressor gene. If the p53 gene in one of your cells becomes damaged and starts to make a protein that does not function properly, that cell can become cancerous. Damaged ( mutated) p53 genes are found in nine out of ten cancers.
a protein that is mutated in some types of tumors.
A gene which normally regulates the cell cycle and protects the cell from damage to its genome.
genes that normally restrain cell growth but, when missing or inactivated by mutation, allow cells to grow uncontrolled.
a suppressor gene. Certain genetic mutations in p53 cause li_fraumeni_syndrome.
A tumour supressor gene that, when working normally, helps to stop cells becoming cancerous. The p53 gene has been found to be damaged in most human cancers.
(See Tumor-suppressor genes.)
(TP53), is a transcription factor that regulates the cell cycle and hence functions as a tumor suppressor. It is very important for cells in multicellular organisms to suppress cancer. p53 has been described as "the guardian of the genome", "the guardian angel gene", or the "master watchman", referring to its role in conserving stability by preventing genome mutation.Strachan T, Read AP. (1999). Human Molecular Genetics 2.
