dominant gene such as the p53 or Rb that suppress cell division. Mutationsin these genes can lead to tumor formation.
A protective gene that normally limits the growth of tumors.
A gene that acts to prevent cell growth. If a mutation occurs in this gene, it may make the individual more susceptible to the development of cancer in the tissue in which the mutation occurs. This effect is a recessive effect in that each of the pair of genes must be abnormal for the tumor promoting action to occur.
a gene Genes are entities that parents pass to offspring during reproduction
a gene whose loss of function contributes to the development of cancer
A gene that normally inhibits excessive cell proliferation. Mutations that permanently disable tumor suppressor genes can cause a cell to grow uncontrollably, leading to tumor development. Examples of tumor suppressors are pRB and p53. pRB (retinoblastoma protein) regulates the cell cycle at cell cycle checkpoints. p53 regulates the activity of certain molecules involved in the cell cycle. It also prevents DNA replication and cell division in normal cells with damaged DNA.
TOO-mer sup-PRESS-er JEAN A gene which, when inactivated or suppressed, causes cancer. 183
A variety of cancer gene that subserves different normal functions. When both copies are mutated or lost, the cessation of the normal function provokes malignant behavior of the cell.
a gene whose function is to monitor and control cell growth
a gene that controls normal growth and cell division; loss or inactivation of such genes are known to contribute to tumor development
Genes that normally restrain cell growth but, when missing or inactivated by mutation, allow cells to grow uncontrolled. Return to alphabet Ultrasonography (ul-tra-son-OG-ra-fee) An exam in which sound waves are bounced off tissues and the echoes are converted into a picture (sonogram).
Genes in the body that can suppress of block the development of cancer.
A type of gene (unit of heredity passed from parent to offspring) that helps control cell growth. Blocking the action of tumor suppressor genes may lead to cancer.
Gene in the body that can suppress or block the development of cancer.
A tumor suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. A mutation or deletion of such a gene will increase the probability of the formation of a tumor.
