Apamea or Apameia (Greek: Απάμεια) – previously, Kibotos (Greek: κιβωτός), hê Kibôtos or Cibotus – was an ancient city in Phrygia, Anatolia, founded by Antiochus I Soter (from whose mother, Apama, it received its name), near, but on lower ground than, Celaenae (Kelainai).

Apamea or Apameia (Greek: Απάμεια) was a Hellenistic city on the left bank of the Euphrates, opposite the famous city of Zeugma, at the end of a bridge of boats (Greek: zeugma) connecting the two, founded by Seleucus I Nicator (Pliny, v. 21). The city was rebuilt by Seleucus I. The site, once partially covered by the village of Tilmusa (formerly Rum-Kala), Şanlıurfa Province, Turkey, is now flooded by the lake formed by the Birecik Dam (Birejik Dam).

Apamea or Apameia (Greek: Απάμεια) was an ancient city – and possibly two ancient cities lying close together – of Babylonia, Mesopotamia mentioned by Stephanus of Byzantium and Pliny as situated near the Tigris near the confluence of the Euphrates, the precise location of which is still uncertain, but it lies in modern-day Iraq.