The situation where a genetic disorder appears to become more severe and/or arise at an earlier age as it is passed through subsequent generations (seen in many trinucleotide repeat mutations).
The previous use, documentation, or acknowledgement of an invention, preventing the patent of the invention.
The tendency for some autosomal dominant diseases to manifest at an earlier age and to increase in severity with each succeeding generation. Example: myotonic dystrophy
The tendency of some genetic conditions to increase in severity, e.g. myotonic dystrophy or appear earlier, e.g. Huntington disease, in successive generations of the same family.
The disease process in which symptoms show up earlier and are increasingly severe in each generation.
The tendency in certain genetic disorders for individuals in successive generations to present at an earlier age and/or with more severe manifestations; often observed in disorders resulting from the expression of a trinucleotide repeat mutation that tends to increase in size and have a more significant effect when passed from one generation to the next Related Terms: intrafamilial variability ; mutable normal allele ; trinucleotide repeat ; trinucleotide repeat testing ; variable expressivity
The phenomenon of increased severity and earlier onset of genetic disease when a mutation is transmitted from one generation to the next.
If Parliament has ordered that a matter is to be debated on a certain date and a Member pre-empts discussion on that matter by raising it on an earlier occasion, he is said to be anticipating the matter. This is not permitted under the Standing Orders. S.O. 51.
The basis for refusing to issue a patent or invalidating a patent because every element of the claimed invention was previously disclosed in a single reference.
the phenomenon whereby disease severity increases with each passing generation. Since disease severity is often difficult to measure, anticipation is frequently measured in terms of patient-reported age-of-onset of the disorder. For example, in a disease showing anticipation, a child may have earlier onset than their parent who has earlier onset than their grandparent. [Source: NHBLI/NCBI Glossary
This is when the prior art indicates that a patent application lacks novelty. Application (for patent) Papers comprising petition, specification, drawings (when required), one or more claims, oath or declaration and filing fee, whereby an applicant seeks a patent.
The process whereby some genetic diseases get more severe in each successive generation.
A condition that exists when claimed invention is not novel in view of the prior art. To anticipate a claimed invention, a prior art reference must teach every element of the claim.
In patent law, a situation in which an invention is "anticipated" by being too similar to an earlier invention to be considered novel. Because novelty is a requirement for a patent, anticipated inventions are not patentable. Anticipation can occur when a prior invention or printed publication matches all of the primary characteristics of the invention, or it can happen when the invention is displayed or offered for sale more than a year prior to filing a patent application. For example, a bird owner invents a device to keep her bird from picking at its tail feathers. She applies for a patent, but her application is rejected on the ground that the same device was in use 3500 years ago in Egypt. In patent-speak, the inventor's creation has been anticipated by previous developments (the prior art.)
Each generation of offspring has increased severity of a genetic disorder; e.g., a grandchild may have earlier onset and more severe symptoms than the parent, who had earlier onset than the grandparent. See also: additive genetic effects, complex trait
A genetic phenomenon where a disease increases in severity in successive generations, and children can have a more severe form of a disease than their parents. A pattern of anticipation is often observed in trinucleotide repeat disorders. For example, in HD children often have earlier an age of onset and experience a more rapid development of the disease.
In medicine, anticipation is a phenomenon whereby the symptoms of a genetic disorder become apparent at an earlier age as it is passed on to the next generation. In most cases, an increase of severity of symptoms is also noted. It is common in trinucleotide repeat disorders like Huntington's disease, myotonic dystrophy and fragile X syndrome, where triplet repeat mutations in DNA are implicated.