Speak is the Tick's pet on the animated version of "The Tick". The Tick found him in the jungles of Mexico after he bumped his head, which made him hallucinate the animal speaking. He thought it was a dog until he took it to the veterinarian, who told him it was in actuality a Capybara.
SPEAK, the Voice for the Animals is a British animal rights campaign that aims to end animal experimentation and vivisection in the UK. Its current focus is opposition to a new animal testing center being built by Oxford University.
SPEAK (Suicide Prevention Education Awareness for Kids) is a non-profit organization that was founded in Maryland in 1999. It "promotes the prevention of youth suicide and works to dispel the social stigma surrounding suicide and depression through a campaign of education and awareness at the community level."