1. An opportunistic infection caused by a type of bacteria, Mycobacterium avium intracellulare (MAI), found in soil and dust particles. 2. A bacterial infection that can be limited to a specific organ or area of the body or spread throughout the body. It is a life-threatening disease, although new therapies offer promise for both prevention and treatment. MAC disease is extremely rare in persons who are not infected with HIV.
mycobacterium avium complex. a disease caused by Mycobacterium avium or Mycobacterium intracellular (sometimes referred to as Mycobacterium avium-intracellular or MAI), bacteria found in soil and water. In immunosuppressed persons, the bacteria can infect the lymph nodes, intestines, bone marrow, liver, spleen, spinal fluid, lungs and the gastrointestinal tract. MAC is the most common bacterial infection in persons with advanced AIDS (usually under 50-75 CD4 cells/mm3). Symptoms include diarrhea, wasting, fever, night sweats, fatigue and spleen enlargement. Clarithromycin is used as treatment and prophylaxis for MAC.
A serious opportunistic infection caused by two similar bacteria (Mycobacterium avium and Mycobacterium intercellulare) found in the soil and dust particles. In AIDS, MAC can spread through the bloodstream to infect lymph nodes, bone marrow, liver, spleen, spinal fluid, lungs and intestinal tract. Typical symptoms of MAC include night sweats, weight loss, fever, fatigue, diarrhea and enlarged spleen. MAC is usually found in people with CD4 counts below 100. MAC is also called MAI.